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Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders

Shipments Will Have a 1-2 Week Delay as We Fulfill Pre-orders
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Cerebral Torque

Cerebral Tranquility Nighttime Gummy with CBN

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Cerebral Tranquility is made with organic ingredients and is 100% vegan, gluten-free, and soy-free. No high fructose corn syrup, no artificial flavors, and no synthetic colors.

TorqueGlide, our topical applicator, has no artificial dyes!

Cerebral Tranquility

Fall asleep faster and wake refreshed with our premium CBN (cannabinol) & Melatonin gummies. Natural watermelon flavor supports deep sleep, mind calming, and recovery.

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TorqueGlide


Experience fast-acting, non-sticky relief for migraine and muscle pain with our premium topical gel. Features cooling natural menthol (and much more!) that works quickly without residue or lingering scent. Perfect for neck, temple, and beyond-hairline application.

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Real Reviews, From Real Migraine Patients

Cerebral Tranquility Nighttime Gummy with CBN
Cerebral Tranquility Nighttime Gummy with CBN
Cerebral Tranquility Nighttime Gummy with CBN
Cerebral Tranquility Nighttime Gummy with CBN

Kara

A testimonial

Amazing!
Cerebral Tranquility Gummies have been so helpful both with getting sufficient sleep and migraine prevention. I've suffered from migraines for most of my life, and I've had daily migraines since August of 2020. I've tried nearly every intervention possible. I recently had a procedure that helped significantly reduce my migraines, but I still got them terribly during my menstrual cycle and with barometric pressure changes. I've been taking one gummy at night for a little over three weeks and I just finished my cycle with no migraines for the first time in years, AND there was rain and thunderstorms for the first few days. This is unheard of for me. I just subscribed to a monthly delivery. Amazing product!

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Ubrelvy is contraindicated with strong CYP3A4 inhibitors because these drugs block the liver enzyme that breaks down Ubrelvy, causing dangerous 5-6x increases in blood levels. All gepants (Ubrelvy, Nurtec, Qulipta) share this interaction since they're all metabolized by CYP3A4. Common inhibitors include ketoconazole and clarithromycin. Follow @cerebral_torque for more
Ubrelvy is contraindicated with strong CYP3A4 inhibitors because these drugs block the liver enzyme that breaks down Ubrelvy, causing dangerous 5-6x increases in blood levels. All gepants (Ubrelvy, Nurtec, Qulipta) share this interaction since they're all metabolized by CYP3A4. Common inhibitors include ketoconazole and clarithromycin. Follow @cerebral_torque for more
This means that if you're dealing with migraine, there's a much higher chance you might also be experiencing things like difficulty concentrating, restlessness, or trouble staying organized. For patients and families, this research helps explain why someone with migraine might also struggle with attention or focus issues, and it suggests that treating both conditions together might lead to better outcomes than treating each one separately. Study: https://doi.org/10.1186/s12883-018-1149-6
This means that if you're dealing with migraine, there's a much higher chance you might also be experiencing things like difficulty concentrating, restlessness, or trouble staying organized. For patients and families, this research helps explain why someone with migraine might also struggle with attention or focus issues, and it suggests that treating both conditions together might lead to better outcomes than treating each one separately. Study: https://doi.org/10.1186/s12883-018-1149-6
There is a association between obesity and migraine, with the relationship being stronger for chronic migraine. The association involves inflammatory mediators called adipokines (hormones from fat cells), altered pain processing, and shared genetic factors. This isn't about appearance - it's about how weight affects inflammation and brain chemistry. In fact, weight changes in either direction can impact migraine frequency. Yes, underweight people also experience inc migraine frequency.
There is a association between obesity and migraine, with the relationship being stronger for chronic migraine. The association involves inflammatory mediators called adipokines (hormones from fat cells), altered pain processing, and shared genetic factors. This isn't about appearance - it's about how weight affects inflammation and brain chemistry. In fact, weight changes in either direction can impact migraine frequency. Yes, underweight people also experience inc migraine frequency.
COVID-19 worsens migraine patterns in patients with pre-existing migraine, causing increased frequency, severity, and treatment resistance. Patients experienced major changes post-infection, with reduced medication effectiveness and new neurological symptoms like brain fog and aphasia. Read my analysis here: https://www.cerebraltorque.com/blogs/migrainescience/how-covid-19-changes-migraine-patterns
COVID-19 worsens migraine patterns in patients with pre-existing migraine, causing increased frequency, severity, and treatment resistance. Patients experienced major changes post-infection, with reduced medication effectiveness and new neurological symptoms like brain fog and aphasia. Read my analysis here: https://www.cerebraltorque.com/blogs/migrainescience/how-covid-19-changes-migraine-patterns
This study found that prenatal exposure to triptans (migraine medications), whether used alone or combined with other migraine medications, does not substantially increase the risk of neurodevelopmental disorders in children followed up to 14 years of age. Study: https://doi.org/10.1212/WNL.0000000000213678 #migraine #autism #triptan #developmentaldisorder
This study found that prenatal exposure to triptans (migraine medications), whether used alone or combined with other migraine medications, does not substantially increase the risk of neurodevelopmental disorders in children followed up to 14 years of age. Study: https://doi.org/10.1212/WNL.0000000000213678 #migraine #autism #triptan #developmentaldisorder
This study found that people with migraine showed objective cognitive impairments in working memory and cognitive inhibition during migraine attacks (ictal phase) compared to headache-free periods (interictal phase). Study: https://doi.org/10.1111/head.14964 #migraine #headache #cognition
This study found that people with migraine showed objective cognitive impairments in working memory and cognitive inhibition during migraine attacks (ictal phase) compared to headache-free periods (interictal phase). Study: https://doi.org/10.1111/head.14964 #migraine #headache #cognition
The minimal transfer of ubrogepant into breast milk (less than 0.02% of a 100mg dose) with a low relative infant dose of 0.15% is not considered clinically relevant. This suggests the medication could be a safe treatment option for migraine in breastfeeding women. Study: https://doi.org/10.1111/head.14960 #migraine #headache #motherhood #babybump
The minimal transfer of ubrogepant into breast milk (less than 0.02% of a 100mg dose) with a low relative infant dose of 0.15% is not considered clinically relevant. This suggests the medication could be a safe treatment option for migraine in breastfeeding women. Study: https://doi.org/10.1111/head.14960 #migraine #headache #motherhood #babybump
This study found that pediatric migraine patients show significant vascular changes in the eye's choroid layer, especially in those with aura. The researchers observed increased choroidal thickness, larger total and luminal areas, and higher vascular index compared to healthy controls. These findings suggest important vascular involvement in childhood migraine and potential differences in migraine pathophysiology between pediatric and adult populations. Study: https://doi.org/10.1111/ped.70059
This study found that pediatric migraine patients show significant vascular changes in the eye's choroid layer, especially in those with aura. The researchers observed increased choroidal thickness, larger total and luminal areas, and higher vascular index compared to healthy controls. These findings suggest important vascular involvement in childhood migraine and potential differences in migraine pathophysiology between pediatric and adult populations. Study: https://doi.org/10.1111/ped.70059
This study found that both aerobic and combined exercise programs can reduce monthly migraine headache frequency without side effects, with the combined exercise program showing statistically better results. This suggests that incorporating both aerobic and resistance exercises may be more beneficial for migraine prevention than aerobic exercise alone. Study: https://doi.org/10.1111/head.14951 #migraine #headache #exercise
This study found that both aerobic and combined exercise programs can reduce monthly migraine headache frequency without side effects, with the combined exercise program showing statistically better results. This suggests that incorporating both aerobic and resistance exercises may be more beneficial for migraine prevention than aerobic exercise alone. Study: https://doi.org/10.1111/head.14951 #migraine #headache #exercise
A recent study found that common acid-reducing medications called proton pump inhibitors (PPIs) such as omeprazole (Prilosec), esomeprazole (Nexium), and pantoprazole (Protonix) are associated with an increased risk of developing migraine, with the risk growing higher the more medication is taken over time. People with the highest exposure to PPIs had a 60% higher risk of migraines compared to those with minimal exposure. Study: https://doi.org/10.1093/postmj/qgaf077 #migraine #headache #ppi
A recent study found that common acid-reducing medications called proton pump inhibitors (PPIs) such as omeprazole (Prilosec), esomeprazole (Nexium), and pantoprazole (Protonix) are associated with an increased risk of developing migraine, with the risk growing higher the more medication is taken over time. People with the highest exposure to PPIs had a 60% higher risk of migraines compared to those with minimal exposure. Study: https://doi.org/10.1093/postmj/qgaf077 #migraine #headache #ppi
This study found that migraine patients have microstructural changes in white and gray matter, with neurite loss in specific brain regions that negatively correlates with serotonin and dopamine neurotransmitter systems. These neural changes, which includes axonal demyelination and loss, become more pronounced as migraine progresses from episodic to chronic, highlighting the importance of early treatment intervention. https://doi.org/10.1186/s10194-025-02059-3 - #migraine #headache #neurology
This study found that migraine patients have microstructural changes in white and gray matter, with neurite loss in specific brain regions that negatively correlates with serotonin and dopamine neurotransmitter systems. These neural changes, which includes axonal demyelination and loss, become more pronounced as migraine progresses from episodic to chronic, highlighting the importance of early treatment intervention. https://doi.org/10.1186/s10194-025-02059-3 - #migraine #headache #neurology
Pick the right menthol product. Topical menthol provides effective pain relief by activating cold-sensitive TRPM8 receptors, creating a cooling sensation that blocks pain transmission. Its effective against migraine pain, allodynia, musculoskeletal pain, neuropathic pain, and sports injuries. The concentration is crucial: at 3.5-5%, menthol therapeutic benefit. However, higher concentrations risk inducing cold allodynia and hyperalgesia, potentially worsening pain rather than relieving it.
Pick the right menthol product. Topical menthol provides effective pain relief by activating cold-sensitive TRPM8 receptors, creating a cooling sensation that blocks pain transmission. Its effective against migraine pain, allodynia, musculoskeletal pain, neuropathic pain, and sports injuries. The concentration is crucial: at 3.5-5%, menthol therapeutic benefit. However, higher concentrations risk inducing cold allodynia and hyperalgesia, potentially worsening pain rather than relieving it.
Statin effectiveness for migraine prevention varies based on: Lifestyle factors: smoking status, alcohol consumption, physical activity levels, dietary patterns AND Comorbidities: hypercholesterolemia, migraine with/without aura, active vs. inactive migraine status, endothelial dysfunction, neuropeptide activity variations - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache #statins
Statin effectiveness for migraine prevention varies based on: Lifestyle factors: smoking status, alcohol consumption, physical activity levels, dietary patterns AND Comorbidities: hypercholesterolemia, migraine with/without aura, active vs. inactive migraine status, endothelial dysfunction, neuropeptide activity variations - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache #statins
This new study found that a 12-week co-supplementation of multispecies probiotics (4.5 × 10¹¹ CFU daily) plus vitamin D (50,000 IU biweekly) significantly reduced migraine index scores by 30.11 points and altered nitric oxide levels in adult migraine patients compared to placebo treatment. This is the first study that coadministered these supplements. Study: https://link.springer.com/article/10.1007/s00394-025-03687-w #migraine #headache #vitaminD #probiotics
This new study found that a 12-week co-supplementation of multispecies probiotics (4.5 × 10¹¹ CFU daily) plus vitamin D (50,000 IU biweekly) significantly reduced migraine index scores by 30.11 points and altered nitric oxide levels in adult migraine patients compared to placebo treatment. This is the first study that coadministered these supplements. Study: https://link.springer.com/article/10.1007/s00394-025-03687-w #migraine #headache #vitaminD #probiotics
The history of migraine disorder spans over 3,500 years, first documented in Egyptian medical texts (1550 BC). For millennia, individuals with migraine endured ineffective treatments like skull drilling and garlic in head incisions. The first real breakthrough came in the 1920s with ergotamine, derived from rye fungus, which could abort attacks. Treatment significantly advanced with triptans in the 1990s and modern CGRP inhibitors in 2018. #migraine #headache
The history of migraine disorder spans over 3,500 years, first documented in Egyptian medical texts (1550 BC). For millennia, individuals with migraine endured ineffective treatments like skull drilling and garlic in head incisions. The first real breakthrough came in the 1920s with ergotamine, derived from rye fungus, which could abort attacks. Treatment significantly advanced with triptans in the 1990s and modern CGRP inhibitors in 2018. #migraine #headache
This study shows a genetic link between migraine and spontaneous coronary artery dissection (SCAD), a condition where an artery in the heart suddenly tears without warning. People with genetic markers for SCAD were more likely to have migraine across all ethnic groups studied, suggesting these two seemingly different conditions might share some underlying genetic causes. Study: https://www.ahajournals.org/doi/10.1161/JAHA.124.036525 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
This study shows a genetic link between migraine and spontaneous coronary artery dissection (SCAD), a condition where an artery in the heart suddenly tears without warning. People with genetic markers for SCAD were more likely to have migraine across all ethnic groups studied, suggesting these two seemingly different conditions might share some underlying genetic causes. Study: https://www.ahajournals.org/doi/10.1161/JAHA.124.036525 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
A recent discovery revealed that individuals with migraine often have lower levels of anandamide (AEA) in their cerebrospinal fluid. Anandamide, whose name comes from the Sanskrit word "ananda" meaning "bliss," is one of your body's natural endocannabinoids. It's essentially your body's version of THC (the active compound in cannabis), though much milder! This connection explains why some people with migraine report finding relief with CBN, CBG, CBD, etc., or medical cannabis products. These products can interact with the same receptors as your body's natural endocannabinoids, potentially compensating for what might be an endocannabinoid deficiency in migraine patients. The recent research shows that AEA has particularly strong pain-reducing effects on the nerve pathways involved in migraine, which is why products that boost anandamide levels (like certain cannabinoid formulations that inhibit the FAAH enzyme that breaks down anandamide) might be promising for migraine treatment. - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
A recent discovery revealed that individuals with migraine often have lower levels of anandamide (AEA) in their cerebrospinal fluid. Anandamide, whose name comes from the Sanskrit word "ananda" meaning "bliss," is one of your body's natural endocannabinoids. It's essentially your body's version of THC (the active compound in cannabis), though much milder! This connection explains why some people with migraine report finding relief with CBN, CBG, CBD, etc., or medical cannabis products. These products can interact with the same receptors as your body's natural endocannabinoids, potentially compensating for what might be an endocannabinoid deficiency in migraine patients. The recent research shows that AEA has particularly strong pain-reducing effects on the nerve pathways involved in migraine, which is why products that boost anandamide levels (like certain cannabinoid formulations that inhibit the FAAH enzyme that breaks down anandamide) might be promising for migraine treatment. - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
The PRODROME trial's demonstrated effectiveness of ubrogepant on prodromal symptoms represents an important advancement in migraine treatment. The ability to intervene during the prodromal phase could prevent progression to the headache phase and reduce overall disability from migraine attacks. Furthermore, findings highlight how blocking CGRP receptors can affect various symptoms beyond just headache pain, including cognitive symptoms, which suggests a central nervous system site of action for these medications. Study: https://www.neurology.org/doi/10.1212/WNL.0000000000209745 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache #ubrelvy
The PRODROME trial's demonstrated effectiveness of ubrogepant on prodromal symptoms represents an important advancement in migraine treatment. The ability to intervene during the prodromal phase could prevent progression to the headache phase and reduce overall disability from migraine attacks. Furthermore, findings highlight how blocking CGRP receptors can affect various symptoms beyond just headache pain, including cognitive symptoms, which suggests a central nervous system site of action for these medications. Study: https://www.neurology.org/doi/10.1212/WNL.0000000000209745 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache #ubrelvy
"In this study, rizatriptan was ineffective at 1 hour for treating vestibular migraine attacks and had limited benefit on symptoms at 24 hours. Findings do not support using rizatriptan for vestibular migraine attacks." Study from JAMA: https://jamanetwork.com/journals/jamaneurology/article-abstract/2833458 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
"In this study, rizatriptan was ineffective at 1 hour for treating vestibular migraine attacks and had limited benefit on symptoms at 24 hours. Findings do not support using rizatriptan for vestibular migraine attacks." Study from JAMA: https://jamanetwork.com/journals/jamaneurology/article-abstract/2833458 - Follow @cerebral_torque for everything migraine. Check the bio for more information. #migraine #headache
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How to Manage CGRP Injection Site Reactions

Tue, Jun 03, 25

How to Manage CGRP Injection Site Reactions

Learn how to manage CGRP injection site reactions with proven tolerance protocols. Complete guide for patients experiencing skin reactions to Aimovig, Ajovy, Emgality with step-by-step treatment plans, medication alternatives, and...

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New Safety Insights from CGRP Antibody Study

New study of 14,285 patients reveals CGRP antibodies (Aimovig, Ajovy, Emgality, Vyepti) remain safe for migraine prevention. Researchers identified 15 potential safety signals, including palpitations and throat pain with eptinezumab,...

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Fri, May 30, 25

Gepants

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Tue, May 27, 25

Complete Guide to Triptans

Complete guide to triptans for migraine treatment: compare all 7 FDA-approved options (sumatriptan, rizatriptan, eletriptan, zolmitriptan, naratriptan, almotriptan, frovatriptan), dosing, side effects, contraindications, and selection criteria for patients and healthcare...

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