1 4

Cerebral Torque

Noci-Calm™ Gummies

Noci-Calm™ Gummies

$23.40 USD
$23.40 USD
Sale Sold out
Shipping calculated at checkout.

Noci-Calm™ Advanced Neurological Support Formula

Experience the science of serenity with Noci-Calm™ - where advanced neuroscience meets natural wellness.

Drawing from research in neuroscience and pain modulation, Noci-Calm™ represents recommended supplementation for natural migraine and headache support[1]. Our name derives from "nociception" - the neural process of encoding and processing noxious stimuli - reflecting our science-based approach to neurological wellness[2].

Key Active Ingredients

📍 Pyridoxine HCl (Vitamin B6) - 4mg

Research demonstrates B6's crucial role in:

  • Serotonin biosynthesis and regulation[3]
  • Homocysteine metabolism, with elevated levels linked to migraine occurrence[4]
  • Neurotransmitter modulation affecting nociceptive pathways[4,5]
  • Anti-inflammatory cascade activation[5]

🌿 Passiflora incarnata (Passionflower) Extract - 20mg

Clinical studies validate its effects on:

  • GABA receptor modulation, comparable to conventional anxiolytics[6,7]
  • Neurogenic inflammation reduction[8]
  • Vasodilatory response regulation[9]
  • Central nervous system calming without cognitive impairment[10,11]
  • Multiple randomized controlled trials demonstrate efficacy equal to standard anxiety medications with superior tolerability[12]

🌙 Melatonin - 2mg

Evidence-based benefits include:

  • Regulation of circadian rhythm disorders associated with migraine[13]
  • Antioxidant activity in neural tissues[14]
  • Modulation of neurovascular inflammation[15]
  • Demonstrated reduction in migraine frequency and intensity in clinical trials[16]

Mechanism of Action

Noci-Calm™ operates through multiple complementary pathways:

1. Neurotransmitter Modulation

Optimizing serotonin and GABA function[17]

2. Anti-inflammatory Response

Reducing neurogenic inflammation[18]

3. Circadian Regulation

Supporting healthy sleep-wake cycles[19]

4. Antioxidant Protection

Defending against oxidative stress in neural tissues[20]

References

  1. Eigenbrodt AK, et al. (2021). Diagnosis and management of migraine in ten steps. Nat Rev Neurol, 17:501-14.
  2. Kursun O, et al. (2021). Migraine and neuroinflammation: The inflammasome perspective. J Headache Pain, 22(1):55.
  3. Liampas I, et al. (2020). Serum homocysteine, pyridoxine, folate, and vitamin B12 levels in migraine. Headache, 60(8):1508-34.
  4. Nattagh-Eshtivani E, et al. (2018). The role of nutrients in migraine headaches. Biomed Pharmacother, 102:317-25.
  5. Khan J, et al. (2021). Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine. Biomed Pharmacother, 139:111557.
  6. Appel K, et al. (2011). Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res, 25:838-43.
  7. Janda K, et al. (2020). Passiflora incarnata in Neuropsychiatric Disorders. Nutrients, 12:3894.
  8. Aman U, et al. (2016). Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia. BMC Complement Altern Med, 16:77.
  9. Grundmann O, et al. (2008). Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract. Planta Med, 74:1769-73.
  10. Movafegh A, et al. (2008). Preoperative oral Passiflora incarnata. Anesth Analg, 106:1728-32.
  11. Dantas LP, et al. (2017). Effects of passiflora incarnata and midazolam for control of anxiety. Med Oral Patol Oral Cir Bucal, 22:e95-e101.
  12. Akhondzadeh S, et al. (2001). Passionflower in the treatment of generalized anxiety. J Clin Pharm Ther, 26:363-7.
  13. Nelakuditi B, et al. (2024). Efficacy of Melatonin as a Promising Intervention for Migraine Prevention. Cureus, 16(10):e72559.
  14. Gelfand AA, et al. (2017). Home-based trials in adolescent migraine. JAMA Neurol, 74:744-5.
  15. Gonçalves AL, et al. (2016). Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention. J Neurol Neurosurg Psychiatry, 87:1127-32.
  16. Peres MF. (2011). Melatonin for migraine prevention. Curr Pain Headache Rep, 15:334-5.
  17. Elsas SM, et al. (2010). Passiflora incarnata L. (Passionflower) extracts elicit GABA currents. Phytomedicine, 17:940-9.
  18. Bianchi A, et al. (2004). Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis. Vitam Horm, 69:297-312.
  19. Sánchez-Barceló EJ, et al. (2011). Clinical uses of melatonin in pediatrics. Int J Pediatr, 2011:892624.
  20. Togha M, et al. (2019). Investigation of oxidant/antioxidant balance in patients with migraine. BMC Neurol, 19:323.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ingredients

Active Ingredients: Vitamin B6 (as Pyridoxine Hydrochloride), Passiflora Extract (Passiflora incarnata)(herb), Melatonin

Inactive Ingredients: Glucose Syrup, Sugar, Glucose, Pectin, Citric Acid, Sodium Citrate, Natural Passion fruit flavor, Vegetable Oil (contains Carnauba Wax), Purple Carrot Juice Concentrate (color)

Directions

Take 2 gummies daily, preferably in the evening.

Warning

Talk to your doctor before use if you have any medical conditions, take prescription medications, or plan medical procedures. Not recommended for those under 18 years old. Pregnant or nursing individuals should speak with a physician prior to use.

Storage instructions:
"KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE."

Shipping & Returns

Ships in 0-2 days with tracking number. Arrives within 2-5 days. US only. Quality guaranteed! 14 day return window.

View full details